The Cleveland Clinic Flu shot study for effectiveness

A large observational study from Cleveland Clinic followed 53,000+ employees during the 2024–2025 flu season.

Researchers compared employees who received the flu shot vs. those who didn’t, tracking who later tested positive for influenza. In this dataset, the vaccinated group showed a higher observed rate of positive flu tests (reported effectiveness: -26.9%).

Important context:

• This was an observational study—not a randomized trial

• It’s a preprint (not yet peer-reviewed)

Meanwhile, the Centers for Disease Control and Prevention estimates this season’s flu vaccine reduced outpatient illness risk by ~36–54% in adults.

Natural/alternatives to the flu shot:

Hygiene Habits: Wash hands often with soap and water, avoid touching eyes/nose/mouth, and disinfect frequently touched surfaces (doorknobs, phones).

• Immune-Boosting Nutrition: Eat a diet rich in fruits, vegetables, and lean proteins. Incorporate immune-supporting foods like garlic, ginger, and yogurt.

• Supplement Support: Consider Vitamin C, Vitamin D, and elderberry to support immune function. Note: While some studies suggest elderberry may shorten symptom duration, raw berries are toxic.

• Lifestyle Factors: Prioritize 7–9 hours of sleep, engage in regular moderate physical activity, and practice stress-reduction techniques.

• Environmental Controls: Use a humidifier to keep indoor air from becoming too dry, which helps prevent the flu virus from surviving longer.

• Natural Remedies: Gargle with warm salt water to help kill pathogens